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Re: Combining Prozac and Paxil.... Jay2112

Posted by SLS on April 3, 2022, at 19:42:52

In reply to Re: Combining Prozac and Paxil.... PeterMartin, posted by Jay2112 on April 3, 2022, at 19:13:52

> > People don't do this. Why? Spinning off the 2 MAOIs at once thread...but....
>
> Well, it is actually showing up in the research.
> https://pubmed.ncbi.nlm.nih.gov/34728290/
> This is with youth, but just type in combine ssri pubmed in google, and you will find a whole span.
>
> My take, from actually combining Paxil and Prozac, was that is was good...to a point. Paxil has a mellowing anticholinergic action (not as strong, but similar to Elavil (Amitriptyline). Prozac also works on norepinephrine, and GABA. So...with a small dose of Paxil (5mg) and a regular dose of Prozac (20mg), I was able to get a bit more of a calming effect. But, the caveat, is that for some reason (maybe because of Paxil's stronger effect on serotonin) I developed some severe akathisia...inner restlessness. BUT, this was 15 or so years ago, and my dose of Prozac may have been much higher and/or the Paxil dose was higher.
> It also could have been serotonin syndrome, so you do have to be careful. But, this is not unconventional territory.
>
> Best,
> Jay
>

I think the title of the paper you cited is confusing. What the paper is about is combining one SSRI with cognitive-behavioral therapy. I may have missed something, though.

- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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