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Re: Combining Prozac and Paxil.... PeterMartin

Posted by Jay2112 on April 3, 2022, at 19:13:52

In reply to Combining Prozac and Paxil...., posted by PeterMartin on March 31, 2022, at 17:26:43

> People don't do this. Why? Spinning off the 2 MAOIs at once thread...but....

Well, it is actually showing up in the research.
https://pubmed.ncbi.nlm.nih.gov/34728290/
This is with youth, but just type in combine ssri pubmed in google, and you will find a whole span.

My take, from actually combining Paxil and Prozac, was that is was good...to a point. Paxil has a mellowing anticholinergic action (not as strong, but similar to Elavil (Amitriptyline). Prozac also works on norepinephrine, and GABA. So...with a small dose of Paxil (5mg) and a regular dose of Prozac (20mg), I was able to get a bit more of a calming effect. But, the caveat, is that for some reason (maybe because of Paxil's stronger effect on serotonin) I developed some severe akathisia...inner restlessness. BUT, this was 15 or so years ago, and my dose of Prozac may have been much higher and/or the Paxil dose was higher.
It also could have been serotonin syndrome, so you do have to be careful. But, this is not unconventional territory.

Best,
Jay



Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-


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poster:Jay2112 thread:1119194
URL: http://www.dr-bob.org/babble/20220128/msgs/1119255.html