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Re: combining nardil and parnate rose45

Posted by SLS on March 29, 2022, at 9:28:11

In reply to Re: combining nardil and parnate, posted by rose45 on March 29, 2022, at 8:26:09

> > There are reasons why I ended up in the hospital.
> >
> > This is another example of promoting personal theories without sufficient evidence found to substantiate them.
> >
> > I'm glad you think that my reporting having untoward reactions to combining Parnate and Nardil is without sufficient significance to consider it. What might be an alternate explanation for my reporting a dangerous reaction from combining Parnate and Nardil? Did you take my report into consideration in your musings? I think anyone should have an appreciation for what they don't know.
> >
> > You simply don't know enough to offer an opinion of any kind regarding the safety of combining Parnate and Nardil. Perhaps you can emphasize that you are guessing, and don't know for sure. Obviously, you argue against my report as if it has no significance in your musings. Think about how your presentations might influence readers to combine drugs that can produce untoward reactions that leave one incoherent and unconscious and in need to immediate hospitalization to administer supportive measures. Penal catheterization is not fun.
> >
> > No doctor of mine ever thought combining MAOIs was safe. Taking two MAOIs at the same time was not the objective. My advice is to allow some period of time seperating the last dose of one MAOI and the first dose of the next. I don't know of any peer-reviewed medical article that asserts otherwise.
> >
> > I had to go to the hospital in an ambulance after switching from Nardil to Parnate without waiting period.
> >
> > I am still reticent to declare that we know ALL of the pharmacology of drugs. New dynamics are being discovered for old drugs as technology and creativity yields new observations and theories.
> >
> > I think empirical observations trump theory.
> >
> >
> > - Scott
> Thanks for the warning Scott. Im sure you are not the only one who has had a bad experience.
> Interesting that Ken Gillman who is an expert on MAOIs seems to think that it is safe to cross-switch.
> But he has given me wrong advice in the past too - so it just goes to show how tricky it is to navigate through all the opinions and information.
> And your experience is not theory, it is real and proof that cross-switching these meds is not safe and reliable, even though some people may get away with it.


That's a very safe way of looking at it.

I switched from Parnate to Nardil.


1. Switching from Nardil to Parnate *might* be safer, but not safe enough.

2. Nardil *might* be more serotonergic than Parnate, based upon my experience with clorgyline, which is specific for inhibiting MAO-A. It does not inhibit MAO-B at all. It was considered by the NIH in 1992 when they gave it to me to be the most powerful antidepressant in the world. To me, Nardil felt more like clorgyline than it did like Parnate. For me, Nardil makes me feel much "brighter" than Parnate and less "speedy".

3. Nardil is better for anxiety disorders. However, I don't know the extent to which it improves depression that is accompanied by anxiety without there actually being an anxiety disorder present.

4. I would be very interested to know how Gillman came to his conclusion. Did he offer evidence for his rationale?

I don't know enough about your history to make any recommendations other than to say that if you tried Parnate already - and especially if it helped you at all - Nardil is different enough from Parnate to be worth trying.

* Colonoscopy in a few hours. Yuck.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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