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Re: Psychedelics - Mechanisms

Posted by linkadge on March 24, 2022, at 15:20:50

In reply to Re: Psychedelics - Mechanisms, posted by undopaminergic on March 19, 2022, at 11:05:08

>I think it is important to note that psychedelics >are *partial* agonists at 5-HT2A receptors. >Serotonin is a full agonist and has no (or very >little) psychedelic potential. The antagonists, as >far as I'm aware, are "full antagonists". So you >would expect drugs that block 5-HT2A to antagonise >psychedelics dose-dependently.

From what I understand too, there are some difference in the localization and/or function in 5-ht2a receptors that respond to serotonin vs. hallucinogens. Something about how hallucinogens active different 2nd messenger systems than serotonin. Way above my head.





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