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Re: Psychedelics - Mechanisms

Posted by SLS on March 22, 2022, at 14:11:28

In reply to Re: Psychedelics - Mechanisms, posted by linkadge on March 18, 2022, at 19:40:01

Hi, Linkadge.

> Interesting, I wonder if MCPP, a metabolite of trazodone which is also a 5-ht2a/c agonist might participate in the therapeutic properties of the drug.
> Many psychiatric drugs are 5-ht2a/c antagonists, so it's hard to reconcile their effects when 5-ht2a agonists are apparently effective for a similar set of disorders.
> I read an article about how LSD did *not* share the same lasting antidepressant effects that psilocybin and that researchers had developed analogues of psilocybin which had antidepressant but not hallucinogenic effects.

That's a big WOW.

My concern with trazodone is that it is metabolized into mCPP. mCPP is an agonist at 5-HT2a/c postsynaptic receptors. In addition, mCPP is a NE-alpha2 antagonist.

mCPP is not a good guy. It produces de novo anxiety or exacerbates existing anxiety. It makes OCD worse. It can make depression worse.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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