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Re: Psychedelics - Mechanisms

Posted by linkadge on March 18, 2022, at 19:40:01

In reply to Psychedelics - Mechanisms, posted by SLS on March 15, 2022, at 14:46:12

Interesting, I wonder if MCPP, a metabolite of trazodone which is also a 5-ht2a/c agonist might participate in the therapeutic properties of the drug.

Many psychiatric drugs are 5-ht2a/c antagonists, so it's hard to reconcile their effects when 5-ht2a agonists are apparently effective for a similar set of disorders.

I read an article about how LSD did *not* share the same lasting antidepressant effects that psilocybin and that researchers had developed analogues of psilocybin which had antidepressant but not hallucinogenic effects.





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