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New case study: Metformin Blood Brain Barrier/BP

Posted by PeterMartin on March 13, 2022, at 23:46:44

I've taken Metformin off and on over the past few years so I was looking at the latest research. This is an interesting case study published last week:

"Reversal of insulin resistance is associated with repair of blood-brain barrier dysfunction and remission in a patient with treatment-resistant bipolar depression"

Our findings show that reversal of insulin-resistance using metformin (1000 mg with breakfast and supper for 14 weeks) led to remission in a patient with treatment-resistant bipolar depression (TRBD). Psychiatric symptom rating scales, laboratory tests and blood-brain barrier (BBB) imaging were all performed on one day before and one day after the 14-week trial of metformin. Remission of TRBD was associated with repair of BBB dysfunction. These results highlight BBB pathology as a mechanism contributing to TRBD, and a promising therapeutic and diagnostic target.




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