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Re: Esmethadone helps treatment-resistant depression

Posted by SLS on January 11, 2022, at 21:25:59

In reply to Re: Esmethadone helps treatment-resistant depression SLS, posted by undopaminergic on January 11, 2022, at 12:23:52

> >
> > What do you think of this compound?
>
> It has an interesting name that makes me wonder if this stereoisomer is part of ordinary methadone. Apparently it has no opioid effects.
>
> > It might be worth finding out in what ways it differs from memantine. Memantine pretty much sucks as an depression. It is equally dismal as an anti-Alzheimer's drug.

> Memantine actually worked "too well" in my experience, inducing a manic condition.

My doctor once said that if a given drug never triggers mania in at least some people, it would be relatively ineffective as an antidepressant in general. Sometimes, triggering a hypomania using an antidepressant is the first step in bringing someone out of a refractory depression. The second step is to use an antimanic agent to cap the hypomania while continuing the antidepressant. For some people, their hypomania, if not impacting their life negatively, are left feeling euphoric, having enormous energy, and accelerated thinking. They are often hyperfunctional. Why rock the boat?


> Finding the right dose was difficult. First it worked at less than 10 mg and later I needed about 60 mg. I wonder how high it would have gone if I had kept using it. The reason I didn't was my impulsive massive overdose of it, which was a more or less direct result of the mania. I left the container in plain sight and it was gone when I came back home after hospitalization.

I found myself compulsively changing the dosage of Nardil up and down. It was a bad habit I picked up from one of my doctors in the 1980s.

Ouch.


> It may have applications in Parkinson's disease and tolerance to amphetamines and opioids.
>
> -undopaminergic
>


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