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Re: Novel treatment for schizophrenia SLS

Posted by Jay2112 on December 15, 2021, at 19:25:14

In reply to Novel treatment for schizophrenia, posted by SLS on December 9, 2021, at 8:42:24

>
>
>
> A potential new approach for the treatment for both positive and negative
> symptoms of schizophrenia:
>
>
> -------------------------------------------------------------------------
>

>
> After identifying mGlu1an abbreviation of metabotropic glutamate receptor
> subtype 1as a potentially druggable target, they tested it with a compound that
> enhances its function: a positive allosteric modulator. The PAM was previously
> developed by Conn in close collaboration with other labs in the WCNDD,
> including those of Craig Lindsley, University Professor of Chemistry and
> Pharmacology, and Colleen Niswender, associate professor of pharmacology.
> Using this compound, they found that enhancing the activity of mGlu1 selectively
> increased the activity of specific inhibitory interneurons, restoring their ability to
> inhibit the neuronal circuits they control.
>

So, they are stimulating a glutamate receptor subtype?

Jay


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-


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poster:Jay2112 thread:1117719
URL: http://www.dr-bob.org/babble/20211102/msgs/1117799.html