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Re: Novel treatment for schizophrenia SLS

Posted by undopaminergic on December 14, 2021, at 12:40:23

In reply to Re: Novel treatment for schizophrenia undopaminergic, posted by SLS on December 14, 2021, at 8:30:46

> > > Can something that improves negative symptoms cause depression?
> >
> > Probably not in the same individual, but as you know, a drug that works for someone may not work for someone else.
> >
> > > I dont get it. The two problems sound identical.
> >
> > The anhedonia and apathy are identical, but negative symptoms does not necessarily include a depressed mood, more likely it's flat.
> >
> > -undopaminergic
>
>
>
> While I was hunting for articles that refer to any differences that may exist between anhedonia and apathy,
>

The two are very different in my experience and understanding. Anhedonia is the lack of reward, pleasure, enjoyment from doing things you would normally. While that is of course a symptom that reduces motivation to engage in activities, it's nothing like apathy, which takes away *all* (or most) of the motivation and interest for doing things. I think you could summarise it as anhedonia taking away the "liking" of activities, and apathy taking away the "desire" for activities. You can also call apathy "anticipatory" anhedonia, with "regular" anhedonia being "consummatory".

> I found something that is more important than nomenclature. The dichotomy described in the two major subtypes of Major Depressive Disorder has been applied since 1980. To my knowledge, Michael Liebowitz and the research team at Columbia were the first to identify this difference.
>
> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042519/
>
> "Features of depression: melancholia, anhedonia, apathy
>
> Different types of depression are associated with markedly different symptoms. Depression with melancholic features is associated with anhedonia, lack of mood reactivity, sadness, weight loss, insomnia, psychomotor agitation, and worse mood in the morning. Depression with atypical features, on the other hand, is associated with a distinct cluster of symptoms, and includes leaden paralysis, fatigue, weight gain, hypersomnia, mood reactivity, sensitivity to social rejection, and worse mood in the evening. ...
>

I have a little of both. I have anhedonia, worse mood in the morning, fatigue, and initial insomnia that is followed by hypersomnia.

-undopaminergic


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