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Re: Novel treatment for schizophrenia undopaminergic

Posted by SLS on December 14, 2021, at 8:30:46

In reply to Re: Novel treatment for schizophrenia, posted by undopaminergic on December 13, 2021, at 10:15:27

> > Can something that improves negative symptoms cause depression?
>
> Probably not in the same individual, but as you know, a drug that works for someone may not work for someone else.
>
> > I dont get it. The two problems sound identical.
>
> The anhedonia and apathy are identical, but negative symptoms does not necessarily include a depressed mood, more likely it's flat.
>
> -undopaminergic

While I was hunting for articles that refer to any differences that may exist between anhedonia and apathy, I found something that is more important than nomenclature. The dichotomy described in the two major subtypes of Major Depressive Disorder has been applied since 1980. To my knowledge, Michael Liebowitz and the research team at Columbia were the first to identify this difference.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042519/

"Features of depression: melancholia, anhedonia, apathy

Different types of depression are associated with markedly different symptoms. Depression with melancholic features is associated with anhedonia, lack of mood reactivity, sadness, weight loss, insomnia, psychomotor agitation, and worse mood in the morning. Depression with atypical features, on the other hand, is associated with a distinct cluster of symptoms, and includes leaden paralysis, fatigue, weight gain, hypersomnia, mood reactivity, sensitivity to social rejection, and worse mood in the evening. It is currently unclear whether the inclusion of such profoundly different clusters of symptoms under the umbrella of a single disorder is a help or a hindrance for the development of treatments. The association of tricyclic antidepressants with better outcomes for melancholic depression [12] and bupropion for atypical depression [13], suggests (but does not mandate) differences in the underlying biology."


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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poster:SLS thread:1117719
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