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Re: AXS-05, a Dextromethorphan based AD, coming soon..

Posted by undopaminergic on November 21, 2021, at 13:57:47

In reply to AXS-05, a Dextromethorphan based AD, coming soon.., posted by PeterMartin on November 21, 2021, at 11:13:04

> FDA was supposed to approve AXS-05 in October, but decided they needed more information. Disappointing. It's going to be a game changer for some people, imho. It's basically a combo of Dextromethorphan (Robitussin/cough suppressant) w/ bupropion (Wellbutrin). I had a big addiction to Robitussin (pure Dextromethorphan) in the mid-00s - mainly cause it worked amazingly for my moods.

It worked for me too once. I was unable to repeat the experience.

> The recent study results have been great, and it works on the NMDA receptor so it's novel in method.

Not all that novel if you consider ketamine. It is also a serotonin reuptake inhibitor -- that's why you can't take it with MAOIs.

> Has anyone else been waiting on its release?

It's not very exciting considering both bupropion and dextromethorphan are already clinically available.





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