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Re: Vortioxetine (Brintellix-Trintellix) SLS

Posted by undopaminergic on November 21, 2021, at 13:31:11

In reply to Re: Vortioxetine (Brintellix-Trintellix) undopaminergic, posted by SLS on November 20, 2021, at 16:49:06

> > > Undopaminergic:
> > >
> > > When was the last time you recognized that you had lost an argument?
> > Frankly, I have no idea.
> > However, there *is* no argument, just misunderstanding. I used the word "arbitrary" to mean something else than what it means to you. There seems to be no disagreement about the facts.
> >
> > If it makes you feel better, we can agree to consider you the winner.
> Phew...
> You had me scared there for a moment. I thought I had lost one. It would have been my first.

Are you serious?

> > It's just no competition to me. It's not important, I just made a comment in passing, not expecting I'd be opening a can of worms. Can we move on now?
> Does it really matter in what manner you made a comment - passing or not?

It matters to me, but maybe not to you.

> You made a statement proposing that the classification of drugs is arbitrary. I think this claim of yours is important to look at closely. I have not seen evidence that the FDA chronically classifies the drugs it approves arbitrarily and without deliberation. Perhaps this opinion of yours is more salient to me than it is to you.

It is, apparently.

> What was *your* conceptualization of the word "arbitrary" when you used it (in your own words)?

I elaborated on it a bit in my previous reply. Maybe "not proper", or "for second-rate reasons".

> Can you cite a few instances where the classification of a drug was arbitrary, and by whom? The FDA? Do you think this agency is capricious when it decides what indications to approve a drug for?

I mentioned doxepin. There was also a SSRI that was approved for the indication of premenstrual syndrome, whereas other SSRIs probably are as effective but have not received the same approval.

> The FDA doesn't classify drugs. It only lists the indications for which it determines a drug is effective to treat. Using a drug for any reason other than the indications approved by the FDA is considered "off-label". This is an issue that has obvious importance.


> I found an article that I think helps clarify the reasons for why I place so much importance on examining your thesis. My comments here are not made in passing - obviously.

In my opinion, the official indications are pretty much irrelevant. What matters is what is known (or at least presumed for good reason) to work.





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