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Re: Vortioxetine (Brintellix-Trintellix) undopaminergic

Posted by SLS on November 20, 2021, at 10:15:36

In reply to Re: Vortioxetine (Brintellix-Trintellix) SLS, posted by undopaminergic on November 18, 2021, at 14:21:50

Hi again.

> I never explicitly challenged the FDA. I just said that drug classification is often arbitrary. But that said, FDA approval of certain drugs for certain purposes often has more to do with the applicant's commercial interests. Ie. one company applies for approval of a certain indication for its drug that is pharmacologically equivalent to another company's drug for which the same indication is not sought.

> That is arbitrary.

In what way is it arbitrary? What are some examples that you feel most support your description?

> > > Right. And they had chloral hydrate before barbiturates!
> >
> > Chloral hydrate is not pleasant. I have taken it.
> You mean it lacks recreational potential in contrast to barbiturates and benzodiazepines?

No. It just feels almost like drinking alcohol. It felt yucky. Not pleasant for me.

I like zolpidem (Ambien). It is a potent sleep initiator with a short half-life - much like triazolam (Halcion), which is a benzodiazepine. The only major side effects for me were night-eating and some anterograde amnesia. Anterograde amnesia is more robust with triazolam than with zolpidem.
> > Doxepin is a pretty crappy antidepressant. It had become used more often as a sleep-aid than an antidepressant. However, you never know how any many individuals will respond to an approved antidepressant - like doxepin. I don't happen to know how many respond to doxepin. Maybe no one, but that is not the issue you brought up.

The issue you brought up is the classification of medications based upon nothing. Humans need to categorize things cognitively in order to make sense of world. The FDA uses evidence of efficacy as reported to determine specific indications for a chemical compound (drug). If other clinical properties are discovered and proven to be therapeutic, additional indications are affirmed and published by the FDA. How is that arbitrary?

> Actually it had a lot to do with that. I suggested the classification of doxepin is arbitrary.

Again, I don't understand what you mean by "arbitrary".


Arbitrary: Merriam-Webster

1. not planned or chosen for a particular reason An arbitrary number has been assigned to each district. : not based on reason or evidence I don't know why I chose that one; it was a completely arbitrary decision.

2. done without concern for what is fair or right Although arbitrary arrests are illegal, they continue to occur in many parts of the country.


- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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