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Re: Vortioxetine (Brintellix-Trintellix) SLS

Posted by undopaminergic on November 18, 2021, at 10:25:47

In reply to Re: Vortioxetine (Brintellix-Trintellix), posted by SLS on November 18, 2021, at 2:45:06

> Hi.


> >
> > You know that you never know how a particular drug is going to affect a particular individual. The other options at this time are clomipramine, asenapine, or even venlafaxine. However, the wheels are already in motion as far as vortioxetine is concerned. I'm lucky if I get to try any of them!
> >
> That's a great perspective.

What are you referring to?

> Prior to the 1950s, there were no true antidepressants.

Well, the classification as antidepressant or something else is pretty arbitrary. For example, some primarily antihistaminic drugs have been classified as antidepressants.

> Amphetamines and cocaine had been used in the past. Chlorpromazine (Thorazine), the first antipsychotic, was first introduced in 1952 in France. The first antidepressant approved for depression was iproniazid, a MAOI, in 1958. Imipramine, the first tricyclic, was introduced in 1959. MAOIs and TCAs. That was it. SSRIs didn't emerge in the United States until the approval of fluoxetine in 1987.

Right. And they had chloral hydrate before barbiturates!





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