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Vortioxetine (Brintellix-Trintellix)

Posted by undopaminergic on November 13, 2021, at 12:31:24

Hi all,

I've decided that vortioxetine is worth a try, despite the failure of lurasidone (Latuda) which shares some of the serotonin antagonism (5-HT7 to be specific). It could be that the serotonin 5-HT3 is key, and the only way to know is to try. Memantine is another antagonist at this receptor, and as some of you may recall, it made me manic; I thought it was the NMDA-glutamate antagonism, but I had horrible effects (worst dysphoria I've experienced) with methoxetamine, a powerful NMDA-antagonist. I have yet to try ketamine.

It does help some people with treatment resistant depression. Here is a sample from "I have been taking 20 mg for about 1 month. I feel awesome. I have taken everything you can imagine and no success.".

Most of the reports on this forum seem to have been negative; has anyone had any promising effects from it?





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