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Re: Lybalvi in the us, zyprexa and samidorphan

Posted by undopaminergic on October 29, 2021, at 11:53:18

In reply to Lybalvi in the us, zyprexa and samidorphan, posted by mogger on October 27, 2021, at 21:39:31

> This just came out. Samidorphan addition supposed to quell the weight gain. Samidorphan is being researched for depression. What does everyone think about it could it help with depression?

Samidorphan is a mu-opioid receptor (MOR) antagonist, so I don't think it can relieve depression on its own. However, there is a combination of samidorphan+buprenorphine that I'm sure can be helpful. The samidorphan is supposed to block the (partial) MOR agonism, to avoid opioid dependence, but allow the buprenorphine to function as a kappa-opioid antagonist.





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