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Re: Ritalin + an MAOi = Greater baseline D/NE? undopaminergic

Posted by linkadge on October 15, 2021, at 21:07:00

In reply to Re: Ritalin + an MAOi = Greater baseline D/NE?, posted by undopaminergic on October 11, 2021, at 9:45:01

These are mice with double or triple gene knockouts.

The problem is that the reuptake process is also needed for the recycling of the neurotransmitter. So blocking reuptake does cause activation of the inhibitory autoreceptors slowing firing, but also blocking the resorption of the neurotransmitter for subsequent re-release.

Many reuptake inhibitors do more to 'stabilize' monoamine activity than really enhance it. The exception is the stimulants with a more complex mode of action.





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