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Re: Ritalin + an MAOi = Greater baseline D/NE?

Posted by undopaminergic on October 11, 2021, at 9:45:01

In reply to Re: Ritalin + an MAOi = Greater baseline D/NE? PeterMartin, posted by linkadge on October 8, 2021, at 15:49:26

> Of course, I don't know for sure. Sometimes strange things happen when multiple pathways of neurotransmitter are inhibited. For example, in some animal models of DAT + COMT + MAO inhibition, dopamine levels are significantly reduced vs. normal animals.
>

Are these gene knockouts or are the inhibitions produced in normal animals through drugs?

> Some of this is likely the result of early life modifications in neurotransmission. Also, there are the autoreceptors which slow monoamine firing when synaptic levels become too elevated.
>

This can be counteracted with sulpiride or its workalikes.

-undopaminergic


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