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Re: Ritalin + an MAOi = Greater baseline D/NE?

Posted by PeterMartin on October 6, 2021, at 14:10:53

In reply to Re: Ritalin + an MAOi = Greater baseline D/NE?, posted by linkadge on October 5, 2021, at 19:34:28

> Taking a MAOI with ritalin will likely increase NE/DA signalling (beyond that of an MAOI alone), but I don't know if it will result in chronically elevated NE/DA (i.e. beyond the effect of the drug itself).
> Studies in rats suggest that the 'stereotypy' induced by higher dose ritalin is increased by MAOIs (suggesting additive increased DA signalling). The irreversible MAOIs will result in longer term elevations in NE / DA, but I don't know if ritalin will result in persistent elevations in DA beyond the effect of the drug itself. My guess is no. Ritalin can upregulate the DA transporters over time, and so when the drug wears off, dopamine levels probably drop beyond baseline (i.e. the crash) for a period of time. That being said I have heard positive reviews from the combination.
> Linkadge

Always appreciate your insight Linkadge! Thanks!!




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