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Re: * Correction regarding selegiline / EMSAM SLS

Posted by Jay2112 on September 24, 2021, at 4:55:36

In reply to * Correction regarding selegiline / EMSAM, posted by SLS on September 14, 2021, at 15:42:31

> Should be:
> It is important to know that selegiline / L-deprenyl / EMSAM does not produce an antidepressant response until the dosage is high enough to inhibit MAO-A in addition to the inhibition of MAO-B at lower dosages. Selegiline is selective for MAO-B at the low dosages used to treat Parkinson's, but not at the higher dosages necessary to produce an antidepressant effect. If selegiline were *specific* for MAO-B rather than *selective*, I doubt that it would work to treat depression.
> - Scott

Hey Scott:

Great synopsis of experience/research and experimentation. I read of a few quite solid research studies on the use of a very effective combination of low dose selegiline and 5HTP in tackling dementia in Alzheimer's and Parkinson's.

I have experience with moclobemide from the past, when it first came out here in Canada. I actually did not have to modify my diet *at all*. I don't quite know why, but I (knock on wood) have never had issues with high blood pressure, and in particular, with adrenergic issues. I read that people with a particular adrenergic metabolic gene set have some difficulties with tolerating MAOIs.

But,yeah I had that on/off again effect with moclobemide. I really don't think it is good for people with major anxiety, nor bipolar.

Because I have diabetes, and problems with stomach food motility, I have been looking into some 'hacks' regarding Vagus nerve stimulation. I know it is an old issue, but there is quite a bit of research involving damage to the VN, and how that can really mess us both the brain and the rest of the body.


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-




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