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Re: Is anyone now taking or has taken a TCA? Results? SLS

Posted by undopaminergic on September 23, 2021, at 12:00:54

In reply to Re: Is anyone now taking or has taken a TCA? Results? Mtom, posted by SLS on September 23, 2021, at 9:58:15

> My first robust response to an antidepressant, albeit for less than two weeks, was imipramine at a dosage of 150 mg/day. Upon the failure to retain an antidepressant response at that dosage, I was gradually titrated up to 300 mg/day. Later, I would try 75 mg/day without success.

I've said it before, but I enjoy your anecdotes. I now think this is in part because they remind me of my own psychopharmacological adventures, such as the powerful stimulant effect of sulpiride, and the anti-anhedonic effects of pramipexole. My first dose of selegiline was also a time of some brief joy. My most useful regimen ever, however (rhyme not intended), was the combination of buprenorphine and methylphenidate ("speedball jr."?).

> In 1987, I responded to treatment robustly for a period of six months before mania emerged and the drugs were discontinued. I was being treated with a combination of Parnate 60 mg/day + desipramine 125 mg/day. Parnate monotherapy produced a brief, mild improvement for less than a week. I don't recall with certainty the dosage used, but I think it was 50 mg/day.

I wish I had access to your doctors!

> Not bad for only four drugs.

My current psychiatrist seems to have a preoccupation with using as few drugs as possible. Of course no-one would want to use more drugs for no reason, but with this preoccuption there's a risk treatment may fail just due to misguided idealism.

Anyway, there's finally some news. We are terminating the lurasidone. I don't know yet if I get to try asenapine or clomipramine.





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