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Re: ritanserin, pimavanserin, and lumateperone

Posted by undopaminergic on September 20, 2021, at 8:20:30

In reply to Re: ritanserin, pimavanserin, and lumateperone undopaminergic, posted by linkadge on September 19, 2021, at 16:10:43

> >venlafaxine does not attenuate the tyramine >pressor effect.
>
> I've heard that the in-vivo inhibition (by effexor) of the norepinephrine transporter is higher than would be indicated by traditional measures ...
>

I've heard that too. But it sounds to me like it may be marketing.

> and may point to an alternative binding site for effexor towards the norepinephrine transporter.
>

If it inhibits the noradrenaline transporter through some alternative binding site, wouldn't it inhibit the tyramine pressor effect?

> I had hypertension on effexor at 75mg.
>

Could it be, for example, an imidazoline receptor antagonist?

https://en.wikipedia.org/wiki/Imidazoline_receptor

Or could it be a metabolite?

-undopaminergic


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URL: http://www.dr-bob.org/babble/20210723/msgs/1117009.html