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Re: Help..severe anger.... undopaminergic

Posted by SLS on September 17, 2021, at 15:24:36

In reply to Re: Help..severe anger.... SLS, posted by undopaminergic on September 17, 2021, at 8:22:53

Hi.

> I don't feel this is important enough to spend much time investigating. It is an interesting curiosity. I wouldn't say moclobemide is necessarily a better antidepressant than EMSAM, but I don't have experience with this. You could be right.

What I said was that, by comparison, the reversible inhibitor of MAO-A (RIMA), moclobemide, produces an antidepressant far more robust than selegiline. Unfortunately, the improvement is fairly brief.

It is very common for people to feel *great* on moclobemide within a week or two. Sometimes, they experience a marked improvement within a few days. The problem is, most people do not stay improved. Despite increasing the dosage from the 300 mg/day that they had initially responded to, increasing the dosage up to the maximum dosage of 1200 mg/day still allows for a relapse shortly afterwards. That was my experience, too, but the improvement didn't last for even one week.

I think this is evidence that MAO-A inhibition is sufficient for a robust antidepressant effect, and that reversibility leaves moclobemide impotent, and it is usually incapable of producing a long-term answer for depression.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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poster:SLS thread:1116908
URL: http://www.dr-bob.org/babble/20210723/msgs/1116987.html