Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Help..severe anger.... undopaminergic

Posted by SLS on September 17, 2021, at 3:45:40

In reply to Re: Help..severe anger.... SLS, posted by undopaminergic on September 16, 2021, at 13:08:18

> > >
> > > Why would clorgyline be more effective than the non-selective MAOIs? Is MAO-B inhibition harmful to the treatment of depression?
> >
> > That's a really good question. I don't know the answer to it. I'm guessing that you are referring to a scenario similar to that of citalopram and escitalopram?
> >
>
> I hadn't thought of it like that, but I guess there is an analogy. Just to clarify, I'm wondering why specific MAO-A inhibition with clorgyline would be better than dual MAO-A and MAO-B inhibition with classic MAOIs. MAO-B contributes to dopamine breakdown, so one would think that inhibiting it in addition to MAO-A would be beneficial, rather than the opposite, that is MAO-B inhibition being detrimental.


I'm sure there is a biological reason for why we see this. I just don't know what it is. Selegiline (including EMSAM) does not exert antidepressant effects until the dosage is high enough to lose its selectivity. Both MAO-A and MAO-B become inhibited, yet this drug sucks as an antidepressant. By comparison, the reversible inhibitor of MAO-A (RIMA), moclobemide, produces an antidepressant far more robust than selegiline. Unfortunately, the improvement is farily brief. My guess is that reversibility is a liability. Moclobemide yields a progressive dosage escalation and ultimate failure. In my experience, moclobemide is more anhedonic and motivating than tranylcypromine while it lasts. I was always under the impression that Nardil inhibits more MAO-A than tranylcycpromine does. Maybe you can look into that. I'm a little short on time.

Psychiatry: So many questions. So few answers.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:SLS thread:1116908
URL: http://www.dr-bob.org/babble/20210723/msgs/1116974.html