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Re: ritanserin, pimavanserin, and lumateperone undopaminergic

Posted by SLS on September 13, 2021, at 14:52:09

In reply to Re: ritanserin, pimavanserin, and lumateperone SLS, posted by undopaminergic on September 13, 2021, at 8:10:20


> Last time I checked, I only found one inverse agonist at 5-HT2C, and that was sertindole (Serdolect). I tried it and had to quit due to extreme nasal congestion.

Wasn't there a major problem with sertindole?

For me, nasal congestion is an effect that I am guessing is noradrenergic. Imipramine, desipramine, protriptyline, and a few others. I don't think it happened with amphetamines, but probably methylphenidate (Ritalin). Oh, it just occurred to me that the anticholinergic properties of the oral agents, like some TCAs, might cause it, too, but I'm not sure. Anticholinergics are used *topically* to treat congestion.

What did you think of Trintellix? It made me loopy, despite a couple of neurons firing in the beginning of treatment. Big brain-fog and a hint of derealization. However, I think it set up the brain for an almost tragic reaction to the subsequent switch to Effexor. I can't begin to describe how excruciating my reaction was, except to say that I had committed myself to give in to the inevitabilty of committing suicide when I arrived home from a trip to Minnesota to visit a friend of mine. I didn't dare do it in her house, so I decided to wait until I got home. I stopped the Effexor and was okay to travel in a few days. I have taken Effexor at least a handful of times with some benefit. Suicide never entered my mind while taking it.

Why do I go off on these tangents?


- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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