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Re: SLS: Which brand of Nardil do you take? SLS

Posted by undopaminergic on September 10, 2021, at 11:53:22

In reply to Re: SLS: Which brand of Nardil do you take? sigismund, posted by SLS on September 9, 2021, at 22:53:12

> Hi, Sigi.
>
> > > This is what I'm taking now:
> > >
> > >Nardil - 60 mg/day
> > >nortriptyline - 75 mg/day
> > >Lamictal - 300 mg/day
> > >lithium 300 mg/day
>
>
> > Hi Scott. So the Nardil dose is lower than you have used in the past?
>
>
> Yes. I wish I had 1/2 your memory. Even if I did, I'd still only be a quarter-wit <dumb joke>.
>
> I was over-medicated with Nardil for over a year. When I first started it, I titrated the dosage very gradually - which is an unusual behavior for me. I get very impatient when nothing good is happening and I continue to suffer. I spent the last year jumping between 90-120 mg/day. Each time I changed the dosage - up or down - I would get a brief charge of improvement. It was very confusing. I got caught up in Einstein's definition of insanity: "Doing something over and over again while expecting different results." I decided to experiment with lower dosages of Nardil about a week ago. Bullseye. I began at 60 mg/day. After I continued to be sluggish and irritable, I realized that this was an indicator of insufficient dosing. I moved up to 75 mg/day just today. I feel significantly better with less variability throughout the day. I can only hope it continues.
>
> Dosing with Nardil can be deceptive. Nardil actually inhibits its own metabolism. That means that as the dosage of Nardil increases linearly, the degree of MAO enzyme inhibition increases exponentially. It is similar to the auto-inhibiting pharmacodynamics seen in anti-epileptic drugs.
>
>
> - Scott

Can you reach near 100% MAO inhibition with Nardil?

-undopaminergic


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