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Re: Can mirtazapine (Remeron) cause increased anxiety? SLS

Posted by undopaminergic on August 27, 2021, at 5:14:12

In reply to Re: Can mirtazapine (Remeron) cause increased anxiety? undopaminergic, posted by SLS on August 26, 2021, at 19:37:42

> UD:
> I like asenapine (Saphris). I tried it and it had an unambiguous antidepressant affect. It lasted several weeks - which for me, was impressive. A friend of mine who has schizoaffective disorder (bipolar type), found asenapine to produce a stable antidepressant response with a more or less global improvement, including cognition and memory.

That is impressive, yes.

> Do you have any ideas as to why asenapine would produce such robust cognitive and memory improvements?

Serotonin antagonism; 5-HT2A and -2C. Histamine H2-antagonism. Maybe serotonin 5-HT5 and -6. I would say 5-HT7 too, but I've tested that with lurasidone and I noticed no improvement.

> Do not pass up asenapine unless you have reason to believe that it would be unsafe. I don't know why asenapine has been so neglected.

I addressed that in another message, directed to you; see:

I would appreciate your thoughts on my regimen.





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