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Re: Can mirtazapine (Remeron) cause increased anxiety? SLS

Posted by Jay2112 on August 26, 2021, at 13:33:43

In reply to Re: Can mirtazapine (Remeron) cause increased anxiety? rjlockhart37, posted by SLS on August 25, 2021, at 3:15:03

> > it could be a short term reaction, but i know nothing about mirtazapine, i know more about fluoxetine
> >
> > SLS, link could maybe awnser this
> I cannot tolerate alpha-2 adrenergic antagonists. They fool the presynaptic neuron into manufacturing and releasing extra norepinephrine / noradrenaline.

Interesting. I had my first psychotic episode when I first started mirtazapine. But, I think the eventual down regulation of my norepinephrine/beta-adrenergic receptors by very high-dose Effexor, and the extra norepinephrine produced by mirtazapine, really helped my depressive episodes in my experience with BP II. I learned to cap the mania with carbamazepine, small dose propranolol, and risperidone. Oddly, the addition of amphetamine (or pretty much an extended-release version, Vyvanse) has been amazing, and sustained a smooth antidepressant, pro-social effect for over ten years. As well, high dose Lyrica (for an amazing pro-GABAergic effect!!) has kept me balanced, but with a very controllable anti-anxiety and antidepressant effect.

Anyhow...sorry for going

~Jay :)

Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-




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