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Re: Dopamine agonists downreg/SLS/UD/Linkadge/all? undopaminergic

Posted by Jay2112 on August 26, 2021, at 12:09:20

In reply to Re: Dopamine agonists downreg/SLS/UD/Linkadge/all?, posted by undopaminergic on August 23, 2021, at 2:00:10

> > I have one main concern about dopamine agonists. That is, downregulation of receptors, and development of TD.
> >
>
> I'm afraid there is no way to eat the cake and have it too. When you use dopamine agonists (direct (like pramipexole, bromocriptine) or indirect (like amphetamines and methylphenidate)), you are taking a risk of downregulation.
>
> If you use dopamine *ant*agonists, you are taking a risk of sensitation (leading to TD).
>
> > Most DA agonists carry a warning in pharmaceutical literarure about this...the development of td after some long-term use.
> >
>
> I think you mean antipsychotics. DA agonists do not cause TD (Tardive Dyskinesia), antipsychotics do, especially the old (first generation) ones.
>

Yes...you are right. I was looking at the literature on people with Parkinson's, using an agonist. Especially, using levodopa. Interesting they are finding using agonists like Neupro and Mirapex as first line in Parkinson's instead of l-dopa, actually lessens the on/off switch in the illness for a longer period of time.

I believe all of the DSM-V illness' actually run on a spectrum, like Autism does. (I've worked with Autistic kids and young adults for over 25 years.) I am no pharmacological or psycho-biological expert, but my psychiatrist mentioned this to me when I was his first patient. So many meds are shared in the treatment of psychiatric disorders.

~Jay


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-


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poster:Jay2112 thread:1116533
URL: http://www.dr-bob.org/babble/20210723/msgs/1116701.html