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Re: Dopamine agonists downreg/SLS/UD/Linkadge/all?

Posted by undopaminergic on August 24, 2021, at 1:56:36

In reply to Re: Dopamine agonists downreg/SLS/UD/Linkadge/all?, posted by linkadge on August 23, 2021, at 8:15:13

> Abilify acts as a mixed agonist antagonist. Supposedly it predominantly activates presynaptic autoreceptors which would slow dopamine firing.

I thought it targeted post-synaptic receptors, with high affinity but with a low efficacy, meaning it is predominantly an (modest) agonist at low doses, and because it binds tightly to the receptors, it prevents (endogenous) dopamine from binding to the receptors at higher doses.





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