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Re: Dopamine agonists downreg/SLS/UD/Linkadge/all?

Posted by undopaminergic on August 23, 2021, at 2:00:10

In reply to Re: Dopamine agonists downreg/SLS/UD/Linkadge/all?, posted by Jay2112 on August 22, 2021, at 16:33:45

> I have one main concern about dopamine agonists. That is, downregulation of receptors, and development of TD.

I'm afraid there is no way to eat the cake and have it too. When you use dopamine agonists (direct (like pramipexole, bromocriptine) or indirect (like amphetamines and methylphenidate)), you are taking a risk of downregulation.

If you use dopamine *ant*agonists, you are taking a risk of sensitation (leading to TD).

> Most DA agonists carry a warning in pharmaceutical literarure about this...the development of td after some long-term use.

I think you mean antipsychotics. DA agonists do not cause TD (Tardive Dyskinesia), antipsychotics do, especially the old (first generation) ones.





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