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Re: Dopamine agonists downreg/SLS/UD/Linkadge/all?

Posted by Jay2112 on August 22, 2021, at 16:33:45

In reply to Abilify for Erectile Dysfunction?, posted by Jay2112 on August 20, 2021, at 19:47:35

I have one main concern about dopamine agonists. That is, downregulation of receptors, and development of TD. Most DA agonists carry a warning in pharmaceutical literarure about this...the development of td after some long-term use.

Now, I ABSOLUTELY do not want my DA receptors plowed down. (Some context: When I was a young child, I had a major learning disability, including reading comprehension, math, and spelling. I also had physical co-ordination problems, like balance, doing very basic gymnastics, etc.) These things were in the early 70's, when Ritalin and such were rarely used.
Now, I caught up, mostly. In college, I got two degrees,all on the Dean's honour list. I am now working on my third degree, in some areas, just for interest.

But, I have been on Dexedrine, then Vyvanse, since 1995, when I was 25. That dopamine awakening REALLY made me excel in college, and I didn't feel 'jacked up', just a normal sense of concentration, and a bit of reduction in my shyness. And, I felt much more physically in control of my body.

So, I do definitely do believe there is a strong dopaminergic (Hi UD! :) component, with a possible
lack of DA receptor sensitivity...or something along those lines. My Neurologist suggested I have both overactive parts of the brain and underactive parts, in particular in the left hemisphere. That last part, I don;t quite understand. Very small amounts of SRI's help (like micro-doses), but regular amounts make me feel like crap. SNRI's make me feel like crap, and NDRI's, I have a small partial response to.

Thanks for reading,

Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-




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