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Re: Nortriptyline dosing. undopaminergic

Posted by SLS on August 21, 2021, at 8:36:43

In reply to Re: Nortriptyline dosing., posted by undopaminergic on August 21, 2021, at 2:11:51

Hi, UD.

> >
> > Now, I respond extremely well to lithium, which blocks noradrenaline.
> >
> I'm not aware of such an effect. Maybe you mean glutamate?

Read my post to Jay regarding lithium and its bimodal effects on glutamate activity.

> > I tried nortriptyline (Aventyl) a few times, and I eventually had a few psychotic, manic episodes. See, there is a type of mania called dysphoric mania, which is like taking a boiling hot shower just after falling onto a thousand razorblades. Most people think mania is some euphoric spending spree, having sex with strangers, type of thing.

> For me it was euphoria and spending sprees. So, at least in some respects, I've been lucky.
> > I think you likely know what I am getting at. The noradrenaline is a huge factor in mania...
> >
> For me, it felt a lot more like dopamine.
> -undopaminergic

I can't really offer any comments regarding your experiences and conclusions. I just don't know enough about it. One of my *older* doctors said that he knows of no effective antidepressant that hasn't precipitated a manic reaction in at least some people. I found that even Wellbutrin, once thought to be immune from producing mania, does indeed trigger it.

Ugly stuff, even if it feels like a better high than cocaine. One episode of mania can ruin a life in days that had taken decades to build. The aftermath of a psychotic mania includes embarrassment, being forever remembered as a mentally imbalanced and potentially dangerous mental patient, being ostracized and abandoned by almost everyone, self-inflicted poverty, the loss of respect by friends who become the target of personal insults and rage, etc. Years of depression really doesn't do this - with the exception of poverty.

I know from experience.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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