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Re: Abilify for Erectile Dysfunction?

Posted by undopaminergic on August 21, 2021, at 2:26:55

In reply to Abilify for Erectile Dysfunction?, posted by Jay2112 on August 20, 2021, at 19:47:35

> I have been coming across many studies on Pubmed showing that Abilify can work for ED. In fact, hypersexuality is listed as a possible side effect. A few studies have shown Abilify + bromocriptine (dopamine agonist) works excellent for ED. I am presuming the partial dopamine agonist activity of Abilify is responsible for this. So...I am on a experiment...with 10mg of Abilify and, hoping to taper, up to 10mg of bromocriptine. I am on 2.5mg of bromo right pdoc won't let me start at 10mg.

With bromocriptine, an ergoline-based drug, you should watch out for heart valvulopathy and fibrosis. Why not use pramipexole (Sifrol, Mirapex) or ropinirole (Requip)?

> A couple of questions...1) Would higher dose Abilify work better for ED? (i.e. 30mg?)

Absolutely not. Abilify is an agonist-antagonist, a dopamine partial agonist, and at low doses, it stimulates dopamine receptors but in higher doses, the net effect is to antagonise them -- that is why Abilify is used for schizophrenia and other psychoses. So more is not merrier with Abilify.

I wonder why you'd need Abilify as a dopamine *agonist* when you are already taking one in the form of bromocriptine?

> 3) What would be the best SRI to augment with for a bit more antidepressant qualities, while the bromo and Abilify address the ED problem? I am thinking low dose Prozac or Zoloft.

SRIs have sexual side effects. I think it is called anorgasmia. I think Prozac is less liable to this effect than Zoloft.





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