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Re: Low dose venlafaxine basically an SSRI?

Posted by SLS on August 11, 2021, at 11:53:03

In reply to Low dose venlafaxine basically an SSRI?, posted by NKP on August 8, 2021, at 15:52:17


> I've read that venlafaxine, at doses lower than 225 mg/day, works essentially like an SSRI.

There is no one better to answer that question than Linkadge. He would do a much better job at describing the most up-to-date facts and theories. I will let him address questions of pharmacology.

If you have had multiple treatment failures, don't worry so much about the pharmacology of venlafaxine and consider it a brand new chemical that you are exposing your brain to. Even at low dosages, it might act in the body in ways yet to be discovered. Personally, I responded better to venlafaxine than any SSRI. I had to go to 300 mg/day to gain maximal antidepressant efficacy. For me, side effects waned until they disappeared entirely. As an example of an effect produced by venlafaxine for me and not for any other drug, after my very first dose of 37.5 mg, I became intensely nauseous and dry-heaved for a few minutes. It never reappeared. Different is different. The only drawback to venlafaxine is that it is difficult to discontinue it due to withdrawal effects. Of course, if it works, this wouldn't be an issue if you intended to stay on it in perpetuity.

Let me amplify my point: Is there anyone you know who responded to one SSRI after failing to respond to another?

Good luck.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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