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Re: Low dose venlafaxine basically an SSRI?

Posted by linkadge on August 9, 2021, at 15:51:48

In reply to Re: Low dose venlafaxine basically an SSRI? linkadge, posted by NKP on August 9, 2021, at 10:18:48

It doesn't really make sense to have an SSRI with the side effects of an SNRI. If it has side effects consistent with an SNRI then it must have some effects on norepinephrine.

On paper, venlafaxine's occupancy of the norepinephrine transporter is lowish. However, PET studies have shown much higher occupancy than you'd expect.

https://pubmed.ncbi.nlm.nih.gov/23090625/

https://pubmed.ncbi.nlm.nih.gov/18418363/

https://pubmed.ncbi.nlm.nih.gov/30649319/

Linkadge


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