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Re: Which antidepressants are 'less' activating? SLS

Posted by linkadge on August 6, 2021, at 14:16:29

In reply to Re: Which antidepressants are 'less' activating?, posted by SLS on August 6, 2021, at 2:09:46

>When Prozac and Zoloft had just come out, my >archaic way of thinking was that the TCAs would >show better than the SSRIs.

I am still under the impression that TCAs are slightly more effective than the SSRIs but with a different side effect profile (perhaps more significant side effects for some patients). Some studies show superiority of TCAs in patients with higher inflammatory markers. If you could only chose between, say, amitriptyline and escitalopram, and there was no ability to drop out because of side effects, I would think that amitriptyline would do a better job at dropping depression symptoms. I think this is especially true in patients with a broader range of symptoms (i.e. insomnia, anxiety, anhedonia, energy etc). The amitriptyline group would have more side effects, however.

Apathy, for example, is a somewhat common effect of SSRIs but less so with TCAs.





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