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Re: GABAergic hypofunction in psychosis? Lamdage22

Posted by jay2112 on August 5, 2021, at 18:44:19

In reply to GABAergic hypofunction in psychosis?, posted by Lamdage22 on July 26, 2021, at 21:19:05

> Does increasing GABAergic neurotransmission lessen psychotic symptoms?

There have been studies which suggest a co-relation. Just go to pubmed and search. GABA seems to fall with an increase in l-arginine in psychosis. As well, GABA is decreased by an increase in NDMA agonism associated with an increase in l-glutamine.
Regular "GABA" you find in health food stores does not cross the blood-brain barrier. Lyrica (pregablin) and Neurontin (gabapentin) do, put I am not sure about their use in preventing or treating psychosis. Depakote/Epival also has a pro-GABA effect, and all of those meds are used highly in Bipolar, and quite effective in reducing agitation and mania.

Jay


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-


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