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Re: GABAergic hypofunction in psychosis?

Posted by undopaminergic on August 2, 2021, at 9:51:46

In reply to Re: GABAergic hypofunction in psychosis? Lamdage22, posted by linkadge on August 2, 2021, at 9:27:28

>
> They are also finding that many of the lines between various mental illnesses are blurred. For example, there is a high degree of overlap between the genes that influence bipolar and schizophrenia. This is no surprise given the overlap in efficacy in treatments with these two disorders.
>

I'm accused of having schizophrenia. Funny that I'm not accused of having bipolar, even though there is more evidence for the latter. The former is harder to diagnose with certainty; eg. you need to know how long a psychotic episode has lasted, and you have to find delusions and differentiate them from other theories and beliefs. However, the fact that negative symptoms are a factor does make it easier to diagnose someone with depression as schizophrenic. With bipolar disorder, just one episode of (hypo)mania is enough for diagnosis, although I do not necessarily agree it should be.

> You see the genetic argument as a negative. You see that suggestion that you might have a few bad genes as a negative. I see this as very liberating. The idea that one day I might be able to analyze me genes to guide treatment, or that they might be able to develop more specific targets, or gene therapy etc. as extremely liberating.
>

I see both perspectives. For the time being, having the wrong genes is a difficult thing to do anything about, but it won't be all that long before it's easier to address the genetic component than the environmental.

-undopaminergic


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URL: http://www.dr-bob.org/babble/20210723/msgs/1116220.html