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Re: GABAergic hypofunction in psychosis? Lamdage22

Posted by linkadge on August 2, 2021, at 9:27:28

In reply to Re: GABAergic hypofunction in psychosis?, posted by Lamdage22 on August 1, 2021, at 23:42:58

>Well if my boundaries are respected enough so >that I am not speaking of abuse anymore for a few >years in a row, and I still have symptoms, I am >willing to consider genetics.

I don't know your exact situation. However, it is common for people with mental illness to blame a whole host of factors which would not cause most healthy people to become clinically mentally ill.

>It hasnt been proven yet like down syndrome >etc. Obviously I dont know anything about your >genes.

I would not say that it hasn't been proven. It's that the genetic findings are somewhat diverse. However when you combine the genetic profile of hundreds of thousands of patients with (say) depression, or schizophrenia, or bipolar you DO find genetic differences compared to similar sized samples of patients without depression.

Also there are many studies of twins separated at birth which show a very high rate of concordance. For example, in twins separated at birth with schizophrenia, there is roughly a 50% concordance. This is WAY higher than you would expect by chance. Hence the only explanation is genetics (as the environmental factors are stripped away).

There are genetic influences AND epigenetic influences. Epigentics factors can be altered (to some extent). Although some epigenetic factors become very difficult to alter.

To say that there is no proof of genetics influences in depression is completely false. However, it is false to say that they have found the exact genes that influence everybody's depression.

They are also finding that many of the lines between various mental illnesses are blurred. For example, there is a high degree of overlap between the genes that influence bipolar and schizophrenia. This is no surprise given the overlap in efficacy in treatments with these two disorders. Similarly, there are overlaps in the genes for OCD, ADHD and Autism. Sleep disorders / anxiety disorders and depression also share some common gene clusters. The genetics are starting to prove what we've known for some time.

They can genetically engineer mice that respond to antidepressants. They can also genetically engineer 'treatment resistant' mice that have extra f*ck*d up genes that mean they don't respond to antidepressants.

You see the genetic argument as a negative. You see that suggestion that you might have a few bad genes as a negative. I see this as very liberating. The idea that one day I might be able to analyze me genes to guide treatment, or that they might be able to develop more specific targets, or gene therapy etc. as extremely liberating.





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