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Re: GABAergic hypofunction in psychosis?

Posted by linkadge on August 1, 2021, at 18:14:03

In reply to Re: GABAergic hypofunction in psychosis?, posted by Lamdage22 on August 1, 2021, at 14:51:47

>i dont know how commonly, but it is conceivable >that sometimes patients are errenously considered >to have bad genes and that way dont get the most >appropriate treatment for them.

Just because you have bad genes doesn't mean you can't get effective treatment. Bad genes just means you have a genetic predisposition. That genetic load could be mild (in which case a variety of treatments could work) or it could be severe, in which case a patient may be treatment resistant, or require multiple treatments.

For example, variations in sodium channel genes could predispose to neuronal overactivity. Variations in HPA could predispose to elevated cortisol responses to stressors. Variations in BDNF genes could result in impaired synaptic plasticity. Variations in PER2 genes (circadian rhythm genes) could predispose to being out of sync with typical sleep wake cycles. Variations in AANT or TPH2 genes can predispose to altered metabolism of tryptophan. Alterations in BH4 genes can predispose to reduced monoamine synthesis. Alterations in immune related genes can predispose to elevated immune responses and / or inflammatory responses. The list can go on and on.

Bottom line there are a gazillion different variations that, alone likely do little, but in combination can predispose to mental illness.

For example. I CANNOT gain weight. This sounds completely absurd to many people I tell. Even when I eat a typical 'western diet' I cannot gain a pound. What could explain this other than genetics? This is not bragging because I have lost the genetic lottery when it comes to mental health.





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