Psycho-Babble Medication | about biological treatments | Framed
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Re: GABAergic hypofunction in psychosis?

Posted by Christ_empowered on July 28, 2021, at 11:31:20

In reply to Re: GABAergic hypofunction in psychosis?, posted by linkadge on July 28, 2021, at 8:17:54

some older research (60s-80s, I think) showed a reduction in symptoms (however that's measured?) when stable people on meds were given benzodiazepines on top. some shrinks still use long term sedatives with neuroleptics, both for symptoms control and to help keep the neuroleptic dosage lower and help with some adverse effects.

i skimmed over a review of old research...standard dose valium (40mgs/day?) was compared to prolixin in people headed towards psychosis (prodromal phase), and they both stabilized people.

guess I'm saying...with or without a bona fide gaba-ergic dysfunction of some sort, sedatives that act upon gaba may very well be helpful with some aspects of schizophrenia.




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