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Re: luvox vs other SSRI's

Posted by undopaminergic on July 24, 2021, at 6:43:14

In reply to luvox vs other SSRI's, posted by porkpiehat on July 23, 2021, at 20:26:02

> My knowledge of luvox is that it is the most serotonergic of the SSRIs, so I'm expecting more apathy, weight gain, and sexual problems.

I think escitalopram is the most serotonin-selective of the SSRIs. The most interesting feature of fluvoxamine (Luvox) in my view is its agonism at sigma1-receptors.

> To me, it doesn't make sense to replace lexapro with luvox to treat the obsessiveness caused by the combo of the ssri and lamictal. But I wanted to vet the idea before discarding it offhand.

It does not make much sense to replace a SSRI with another SSRI, except to the extent that the different SSRIs differ in their secondary mechanisms of action.





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