Psycho-Babble Medication | about biological treatments | Framed
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Re: Treatment of bipolar depression sucks

Posted by undopaminergic on July 10, 2021, at 6:05:35

In reply to Re: Treatment of bipolar depression sucks, posted by jay2112 on July 9, 2021, at 20:44:29

> Interesting....
> I have been doing some heavy research on atypical antipsychotics. The ones that antagonize 5-ht2a and 5-ht2c appear quite efficacious in majorly reducing agitation and social anxiety. Yes, Risperidone (Risperdal) binds strongest to those receptors, with a lighter dopamine blockade, and also blocks adrenergic receptors.

I didn't enjoy risperidone at all. It made me feel weak and made me gain a little weight, so I quit. It was my first antipsychotic, and my condition is substantially different from back then. Perhaps for that reason, I've never experienced the feeling of weakness again, despite trying a multitude of other antipsychotics, so maybe I wouldn't if I tried risperidone again.

> The issues with Zyprexa, Saphris, and Seroquel, to name a few, is they also block, very heavily, histamine and muscarnic receptors, and heavy dopamine blockade. Like you said about Seroquel, it's a heavy baby, and it drove me into the abyss!! Haldol seemed like a walk in the park compared to

Actually quetiapine (Seroquel) is one of the weakest dopamine antagonists among antipsychotic drugs. Some say that the action is so weak as to be clinically irrelevant. Meanwhile, haloperidol (Haldol) is one of the most potent dopamine antagonists, and incidentally, one of the most dopamine-selective.

So I agree with what you say below:

> But...this all shows how different we all are. Genetics, environment..etc.

> Saphris caused MAJOR td, at times.

I think you mean EPS (extrapyramidal symptoms) not TD (tardive dyskinesia).





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