Psycho-Babble Medication | about biological treatments | Framed
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Re: Can some of you sci wizs gen ap's

Posted by SLS on June 8, 2021, at 10:26:08

In reply to Re: Can some of you sci wizs gen ap's, posted by undopaminergic on June 4, 2021, at 7:42:19

I think the key with these drugs is that they don't spend very much time attached to the D2 receptor. They hop on and hop off quickly. My guess is that this minimizes dopamine receptor supersensitivity, and thus reduces EPS. The features of the D2R include pieces of the receptor sticking out of the membrane and the formation of pockets within the receptor. The proposed antipsychotics are attracted to these pockets, which don't exist on any other type of dopamine receptor. This effectively makes these drugs not only selective, but perhaps even *specific* to D2R. The other dopamine receptors don't seem to be involved with the therapeutic effects of existing antipsychotics.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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