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Re: 120mg of fluoxetine undopaminergic

Posted by SLS on June 7, 2021, at 21:32:28

In reply to Re: 120mg of fluoxetine SLS, posted by undopaminergic on June 7, 2021, at 7:24:38

Hi UD.

> > Take your list of good ones and evaluate which ones are compatible in combination, but are different enough to be complementary rather than synergistic.
> >
> I think synergy is the ideal; it means the sum is greater than its parts. Usually that involves drugs with complementary effects -- it is hard to imagine achieving synergy with purely additive mechanisms such as SSRI+SSRI.
> Anyway, your thoughts are interesting. Eg. you mention lamotrigine... I'm on 200 mg, without effect; do you think 300 or 400 mg might be dramatically different?
> I'm glad you found a working combination after all this time.
> -undopaminergic

For me, 200 mg/day of Lamictal helped, but didn't really kick-in until I went to 300 mg/day. In 2009, I was on these same four drugs, but with 200 mg/day of Lamictal instead of 300 mg/day. 12 years lost. My mistake. I was so close. I wish I had thought to ask my doctor to go higher. He would have - obviously. 12 years. I was reluctant to go higher with Lamictal because I was concerned about memory and cognitive impairments. I was too smart for my own good. If you do go to 300 mg/day, be patient with any sensation of brain-fog or memory difficulties. With me, these things resolved within a week or two.

Interestingly, 75 mg/day of Nardil doesn't work, but 90 mg/day does. That's not the interesting part, though. I lose my improvement in depression when I go to 105 mg/day or higher. My doctor saw this with another one of his patients. By comparison, there is no such window with me for Parnate. 80 helps. 150 mg/day helps, too. Parnate just gives me more energy without touching anhedonia or global depression.

Three more comments regarding Nardil and my experience with it.

1. It can take as long as three months to begin responding. Of course, that's only 12 weeks. For some reason, 12 weeks sounds shorter to me than 3 months. It took me less than 3 months, but longer than 1 month.

2. Keep in mind that some people have a remarkably hard and narrow dosage window.

3. Starting at 7.5 mg/day (half a pill) and increasing the dosage gradually might avoid or mitigate side effects. It was an experiment. As many times as I have been on Nardil, I experienced orthostatic hypotension to the point of feinting. The dizziness never subsided, even after months and months. I thought that if I avoided triggering the side effects in the first place, they might not develop, or be transient if they did. I think I had two orthostatic episodes since last summer, and they were mild.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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