Psycho-Babble Medication | about biological treatments | Framed
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Re: Do you agree with NMDA hypofunction hypothesis?

Posted by linkadge on June 1, 2021, at 15:56:50

In reply to Re: Do you agree with NMDA hypofunction hypothesis?, posted by Lamdage22 on June 1, 2021, at 2:22:39

It's hard to say whether currently commercially available NMDA agonists are effective in schizophrenia.

I think d-serine is the most studied, and has shown some positive effects in some forms of schizophrenia. Also, l-theanine (which has glutamate enhancing and blocking effects) has also shown some benefit. Ascorbic acid (vitamin C) is also interesting. It has been shown in clinical trials to reduce the necessary dose of neuroleptics. It has glutamate stabilizing effects (acting as a co-transmitter with glutamate) and some mild dopamine reducing effects.

Glutamate modulators have the potential to improve both positive and negative symptoms (perhaps a bit more of the latter). Some recent studies found genes related to NMDA alterations in the prefrontal cortex. Here's a good article:

Not sure if you have heard of anti-nmda autoimmune encephalitis. It is fairly rare, but it is an autoimmune condition where the body produces natural NMDA antagonists. Symptoms include the full range of symptoms of schizophrenia and, if it progresses, seizures as well.

Of course, a lot more research is needed.





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