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Re: Do you agree with NMDA hypofunction hypothesis?

Posted by linkadge on May 31, 2021, at 20:10:22

In reply to Re: Do you agree with NMDA hypofunction hypothesis?, posted by Lamdage22 on May 31, 2021, at 13:44:11

Certainly. Although raising NMDA in a global sense may cause problems. If there are glutamatergic deficits, they may be regional. Hence, nonspecific NMDA agonists could cause excessive glutamate in certain brain regions. In schizophrenia there is evidence of both hypo and hyper function of glutamate (depending on the brain region).

Also, there are interactions with GABA. For instance, for catatonic schizophrenia, benzodiazapines are particularly effective (which is paradoxical as you'd think they would put the catatonic patient into further catatonia). This indicates an imbalance where too little gaba is actually increasing the inhibitory effect of dopamine. Increasing gaba can actually inhibit dopamine induced inhibition. Benzodiazapines can have a paradoxical excitatory effect in certain situations (such as catatonia, and in some cases coma). They can also reverse ketamine induced catatonia. NMDA antagonists tend to shift the balance between dopamine and gaba towards dopamine.




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