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Re: Do you agree with NMDA hypofunction hypothesis?

Posted by undopaminergic on May 31, 2021, at 9:53:57

In reply to Do you agree with NMDA hypofunction hypothesis?, posted by Lamdage22 on May 31, 2021, at 4:00:28

Yes, I tend to consider the NMDA theory of schizophrenia the best one as of currently. I think low NMDA-neurotransmission leads to a *functional* (ie. not in terms of absolute concentrations) hyperdopaminergic state in the limbic system.

D-cycloserine has been tested, with inconsistent but somewhat promising results:


> Hey guys,
> there are several amino acids that can target NMDA recpetpors. Is this always a good idea for schizophrenia? Are there risks?
> I am thinking L-or-D aspartic acid and D-Alanine.




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